Low arterial oxygen partial pressure induces pulmonary thrombocytopenia in patients and a mouse model

Abstract Background Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether pathophysiological state affect platelets little known. We aim to investigate incidence thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated thrombocytopenia. Methods In total, 11,941 were enrolled, other three infectious diseases collected as controls. The was compared, PIN investigated by multivariate analysis. To explore mechanism thrombocytopenia, hypoxic model constructed. Blood counts from angular vein (PLTs), left ventricle (PLT post ) right pre determined. Megakaryocytes identified anti-CD41 antibody detected through flow cytometry immunofluorescence. Results higher than (9.8% vs. 6.4% ~ 5.0%, P < 0.001). Low arterial oxygen partial pressure (PaO 2 an important factor for (OR = 0.88; mouse model, PLTs decreased (518.38 ± 127.92 vs 840.75 77.30, 0.05), which showed low PaO induced difference between PLT (∆PLT post-pre ), representing production lungs, significantly attenuated mice when compared normoxic (F 25.47, 0.05). Additionally, proportions CD41-positive megakaryocytes marrow, spleen all mice. Conclusion There high patients. -induced impaired generation lungs.